Three industrial routes cover micro-pellet production — extrusion-spheronization for high-drug-load pellets, centrifugal pelletizing for nucleus-to-coating in one bowl, and spinning (low-shear) extrusion for heat-sensitive masses. All three run from 0.12 kg lab batches to production with yield above 99%.
The three routes compared
- Extrusion-spheronization (JCD + GY): the classic for 0.2–2 mm sustained-release pellets; dense, spherical, coat-ready.
- Centrifugal pelletizing (LBZ): nucleation, growth and coating in one bowl from 0.2 kg — the fastest R&D loop.
- Spinning low-shear extrusion (FF): for sugar-heavy, thermo-labile masses at up to 1,200 kg/h.
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FAQ
How do I produce spherical pellets with high drug loading?
Extrusion-spheronization — the screw extruder (JCD) pushes the wet mass through a screen and the spheronizer bowl (GY) rounds it; high drug loading is exactly where this route outperforms alternatives.
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